Papel de la proteína ABCG2 en la selección de fármacos y compuestos naturales a leche

Autores

  • Juan Andoni Otero Calzada

DOI:

https://doi.org/10.18002/ambioc.v0i11.5528

Resumo

Estudio sobre la proteína ABCG2 llevado a cabo en el Instituto de Sanidad Animal y Desarrollo Ganadero del Departamento de Ciencias Biomédicas en la Facultad de Veterinaria de la Universidad de León.

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Referências

Cohen-Zinder, M., Seroussi, E., Larkin, D.M., Loor, J.J., Everts-van der Wind, A., Lee, J.H., Drackley, J.K., Band, M.R., Hernandez, A.G., Shani, M., Lewin, H.A., Weller, J.I. y Ron, M. (2005). Identification of a missense mutation in the bovine ABCG2 gene with a major effect on the QTL on chromosome 6 affecting milk yield and composition in Holstein cattle. Genome Research 15:936-944

Jonker, J.W., Merino, G., Musters, S., van Herwaarden, A.E., Bolscher, E., Wagenaar, E., Mesman, E., Dale, T.C. y Schinkel, A.H. (2005). The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk. Nature Medicine 11:127-129.

McManaman, J.L. y Neville, M.C. (2003). Mammary physiology and milk secretion. Advanced Delevery Reviews 55:629-641.

Otero, J.A., Real, R., de la Fuente, A., Prieto, J.G., Marques, M., Alvarez, A.I. y Merino, G. 2013. The bovine ATP-binding cassette transporter ABCG2 Tyr581Ser single-nucleotide polymorphism increases milk secretion of the fluoroquinolone danofloxacin. Drug Metabolism and Disposition 41:546-549.

Perez, M., Otero, J.A., Barrera, B., Prieto, J.G., Merino, G. y Alvarez, A.I. 2013. Inhibition of ABCG2/BCRP transporter by soy isoflavones genistein and daidzein: effect on plasma and milk levels of danofloxacin in sheep. 196:203-208.

Real, R., Gonzalez-Lobato, L., Baro, M.F., Valbuena, S., de la Fuente, A., Prieto, J.G., Alvarez, A.I., Marques, M.M. y Merino, G. 2011. Analysis of the effect of the bovine adenosine triphosphate-binding cassette transporter G2 single nucleotide polymorphism Y581S on transcellular transport of veterinary drugs using new cell culture models. Journal of Animal Sicence. 89:4325-4338.

Woodward, O.M., Kottgen, A., Coresh, J., Boerwinkle, E., Guggino, W.B. y Kottgen, M. 2009. Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout. Proceedings of the National Academy of Sciences USA106:10338-10342.

Publicado

2014-07-18

Como Citar

Otero Calzada, J. A. (2014). Papel de la proteína ABCG2 en la selección de fármacos y compuestos naturales a leche. Ambiociencias, (11), 77–82. https://doi.org/10.18002/ambioc.v0i11.5528

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Secção

Mi proyecto de tesis